Hydrogen Peroxide → HCID 10358802, compound

HRID 465328Notes

Reaction equation

HRID 465328 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]1[N:7]2[C:8]3[C:13]([N:14]=[CH:15][C:6]2=[N:5][N:4]=1)=[CH:12][C:11]([Cl:16])=[C:10]([Cl:17])[CH:9]=3.[OH:20]O>CC(O)=O>[F:19][C:2]([F:1])([F:18])[C:3]1[N:7]2[C:8]3[C:13]([NH:14][C:15](=[O:20])[C:6]2=[N:5][N:4]=1)=[CH:12][C:11]([Cl:16])=[C:10]([Cl:17])[CH:9]=3

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 15667657HCID 15667657, compound

Product 1

HCID 10358802HCID 10358802, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
55 °C

Procedure

800 mg (2.3 mmol) of the quinoxaline (9) was stirred in 22 ml HOAc, and 7 ml of 30% H2O2 was added. The reaction mixture was heated to 55° C. for 16 hours, and then cooled to room temperature. Filtering and drying the product yielded 330 mg of 1-trifluoromethyl-7,8-dichloro-1,2,4-triazolo [4,3-a]quinoxalin-4(5H)-one (10).

Workup

  1. temperaturecooled to room temperature
  2. filtrationFiltering
  3. customdrying the product

Sources & evidence

ORD record
ord-50f3e925a3044acc9949e61809648ae5
Source dataset
uspto-grants-1992_10
Patent number
US05153196

Reaction notes

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