反应详情

To a solution of 2,3-dimethoxycinnamic acid (5.0 g) in tetrahydrofuran (50 ml) was added N,N'-carbonyldiimidazole (4.28 g) and the mixture was stirred at room temperature for 30 minutes. To this was added 3-amino-δ-valerolactam (3.02 g), followed by stirring overnight. The reaction solution was diluted with chloroform and washed with a saturated soldium bicarbonate solution and then dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure and the residue was chromatographed on a silica gel column to obtain the titled compound (2.91 g, 39.8%).

1. stirringby stirring overnight
2. washwashed with a saturated soldium bicarbonate solution
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was removed under reduced pressure
5. customthe residue was chromatographed on a silica gel column