Sodium Hydroxide → HCID 67831580, compound

HRID 465372Notes

Reaction equation

HRID 465372 reaction equation
[ClH:1].[CH3:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)[O:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1.[OH-].[Na+]>CO>[ClH:1].[CH3:30][C:27]1[CH:28]=[CH:29][C:24]([CH:9]([C:6]2[CH:5]=[CH:4][C:3]([CH3:2])=[CH:8][CH:7]=2)[O:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:13][CH2:12]2)=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 21648153HCID 21648153, compound

Product 1

HCID 67831580HCID 67831580, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 3.55 g of ethyl 4-[bis(4-methylphenyl)methoxy]-1-piperidinepropionate hydrochloride, 12.4 ml of 2N sodium hydroxide aqueous solution and 20 ml of methanol was refluxed for 1 hour and then concentrated. Water was added to the residue and made acidic with hydrochloric acid. The resulting precipitate was collected by filtration to give 3.29 g of colorless crystals. The crystals were recrystallized from water to give 2.63 g of colorless needles, mp 159°~162° C.

Workup

  1. temperaturewas refluxed for 1 hour
  2. concentrationconcentrated
  3. additionWater was added to the residue
  4. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-da8236d12f7d4d1798eae59ccd71249d
Source dataset
uspto-grants-1992_10
Patent number
US05153207

Reaction notes

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