Sodium Hydroxide → HCID 67831580, compound

Participants

Reaction Steps

A mixture of 3.55 g of ethyl 4-[bis(4-methylphenyl)methoxy]-1-piperidinepropionate hydrochloride, 12.4 ml of 2N sodium hydroxide aqueous solution and 20 ml of methanol was refluxed for 1 hour and then concentrated. Water was added to the residue and made acidic with hydrochloric acid. The resulting precipitate was collected by filtration to give 3.29 g of colorless crystals. The crystals were recrystallized from water to give 2.63 g of colorless needles, mp 159°~162° C.

Provenance & Evidence