Hydrochloric Acid → HCID 67915647, compound

HRID 465378Notes

Reaction equation

HRID 465378 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[C:23]([F:24])=[C:22]3[C:17]([C:18](=[O:33])[C:19]([C:28]([O:30]CC)=[O:29])=[CH:20][N:21]3[CH:25]3[CH2:27][CH2:26]3)=[C:16]([NH2:34])[C:15]=2[F:35])[CH2:9]1)=O)(C)(C)C.[ClH:36]>C(O)(=O)C>[ClH:36].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[C:23]([F:24])=[C:22]3[C:17]([C:18](=[O:33])[C:19]([C:28]([OH:30])=[O:29])=[CH:20][N:21]3[CH:25]3[CH2:27][CH2:26]3)=[C:16]([NH2:34])[C:15]=2[F:35])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15021544HCID 15021544, compound

Product 1

HCID 67915647HCID 67915647, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 7-(t-butoxycarbonyl-3-pyrrolidinyloxy)-1-cyclopropyl-5-amino-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3carboxylate (105 mg) was similarly treated using 0.5 ml of concentrated hydrochloric acid and 2 ml of acetic acid, whereby 38 mg of the title product was obtained.

Sources & evidence

ORD record
ord-22eba3c1bc1949f5b1b9aed78148d56b
Source dataset
uspto-grants-1992_10
Patent number
US05153203

Reaction notes

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