Hydrochloric Acid → HCID 67915663, compound

HRID 465382Notes

Reaction equation

HRID 465382 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[N:23]=[C:22]3[C:17]([C:18](=[O:37])[C:19]([C:32]([O:34]CC)=[O:33])=[CH:20][N:21]3[C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=3[F:31])=[CH:16][C:15]=2[F:38])[CH2:9]1)=O)(C)(C)C.[ClH:39]>C(O)(=O)C>[ClH:39].[NH:8]1[CH2:12][CH2:11][CH:10]([O:13][C:14]2[N:23]=[C:22]3[C:17]([C:18](=[O:37])[C:19]([C:32]([OH:34])=[O:33])=[CH:20][N:21]3[C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:25]=3[F:31])=[CH:16][C:15]=2[F:38])[CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15021553HCID 15021553, compound

Product 1

HCID 67915663HCID 67915663, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Ethyl 7-(1-t-butoxycarbonyl-3-pyrrolidinyloxy)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (220 mg), 0.7 ml of concentrated hydrochloric acid and 2.8 ml of acetic acid were used. The ester was treated in a similar manner to Example 1-(2) and recrystallized from ethanol, whereby 80 mg of the title compound was obtained.

Workup

  1. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-acbda8e32c874c3992820d3c2f882477
Source dataset
uspto-grants-1992_10
Patent number
US05153203

Reaction notes

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