反应详情

A mixture of 4,5-dihydro-6-(4-acetonyloxyphenyl)3(2H)-pyridazinone (0.3 g) and 2-hydroxy-2-(3-chlorophenyl) ethanamine carbonate (0.26 g) in dry benzene (80 ml) was heated under reflux, with azeotropic removal of water, for 3 hr. The solvent was evaporated and the residue dissolved in methanol (80 ml) and treated with sodium cyanoborohydride (0.5 g). After 18 hr. the methanol was evaporated and the residue partitioned between ethylacetate and brine. The organic phase was washed with water, dried (MgSO4) and evaporated to a gum which was chromatographed on silica gel. Elution with methanol-chloroform (4:96) gave 6-[4-[2-[(3-chloro-β-hydroxyphenethyl)amino]propyloxy]-phenyl]-4,5-dihydro-3(2H)-pyridazinone as a white crystalline solid, m.p.t. 140°-158° C., as a 1:1 mixture of diastereoisomers.

1. temperaturewas heated
2. customThe solvent was evaporated
3. dissolutionthe residue dissolved in methanol (80 ml)
4. additiontreated with sodium cyanoborohydride (0.5 g)
5. customthe methanol was evaporated
6. customthe residue partitioned between ethylacetate and brine
7. washThe organic phase was washed with water
8. dry with materialdried (MgSO4)
9. customevaporated to a gum which
10. customwas chromatographed on silica gel
11. washElution with methanol-chloroform (4:96)