反应详情

A mixture of 4,5-dihydro-6-(p-hydroxyphenyl)-3(2H)pyridazinone (0.55 g), chloroacetone (0.32 g) and potassium carbonate (0.4 g), with a catalytic amount of potassium iodide, was stirred and heated under reflux in acetone (60 ml) for 16 hr. The solvent was evaporated and the residue partitioned between water and ethyl acetate. The organic layer was dried (MgSO4) and evaporated to a gum which was purified by chromatography on Silica gel. Elution with methanol-chloroform (4:96) gave 4,5-dihydro-6-(4-acetonyloxyphenyl)-3(2H)-pyridazinone as a pale yellow solid.

1. temperatureheated
2. customThe solvent was evaporated
3. customthe residue partitioned between water and ethyl acetate
4. dry with materialThe organic layer was dried (MgSO4)
5. customevaporated to a gum which
6. customwas purified by chromatography on Silica gel
7. washElution with methanol-chloroform (4:96)