HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 3,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-(4-Hydroxyphenyl)-6-methyl-3,4-dihydropyridin-2(1H)-one | HCID 13268976 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone | HCID 19874566 | — |
Reaction Steps
A mixture of 3,4-dihydro-5-(4-hydroxyphenyl)-6-methyl-2(1H)-pyridinone (0.94 g), chloroacetone (0.43 g) and potassium carbonate (0.64 g), with a catalytic amount of potassium iodide, was stirred and heated under reflux in acetone (80 ml) for 16 hr. The solvent was evaporated and the residue partitioned between water and ethyl acetate. The organic layer was dried (MgSO4) and evaporated to give 3,4-dihydro-5-(4-acetonyloxyphenyl)-6-methyl-2(1H)-pyridinone as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05153210 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-8e9de204cc9f4536ae735588dc99832d |
| Source note | uspto-grants-1992_10 |