反应详情

A mixture of 4,5-dihydro-6-[4-(2-hydroxypropyl)-phenyl]-3(2H)-pyridazinone (0.23 g) and pyridiniumchlorochromate (0.21 g) in dichloromethane (20 ml) was stirred at ambient tempeature for 18 hr., filtered and evaporated to a gum which was chromatographed on slice gel. Elution with 4% MeOH in CHCl3 gave 4,5-dihydro-6-[(4-acetonyl)phenyl]-3(2H)-pyridazinone as a crystalline solid.

1. filtration, filtered
2. customevaporated to a gum which
3. customwas chromatographed on slice gel
4. washElution with 4% MeOH in CHCl3