HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-dihydro-6-[4-(2-hydroxypropyl)-phenyl]-3(2H)-pyridazinone → 4,5-dihydro-6-[(4-acetonyl)phenyl]-3(2H)-pyridazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-dihydro-6-[4-(2-hydroxypropyl)-phenyl]-3(2H)-pyridazinone | HCID 19874563 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4,5-dihydro-6-[(4-acetonyl)phenyl]-3(2H)-pyridazinone | HCID 54265752 | — |
Reaction Steps
A mixture of 4,5-dihydro-6-[4-(2-hydroxypropyl)-phenyl]-3(2H)-pyridazinone (0.23 g) and pyridiniumchlorochromate (0.21 g) in dichloromethane (20 ml) was stirred at ambient tempeature for 18 hr., filtered and evaporated to a gum which was chromatographed on slice gel. Elution with 4% MeOH in CHCl3 gave 4,5-dihydro-6-[(4-acetonyl)phenyl]-3(2H)-pyridazinone as a crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05153210 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-eb0fa30c90cd472cbeebb36ff1f22630 |
| Source note | uspto-grants-1992_10 |