反应详情

To a solution of 0.218 g methyl 8-(p-chlorophenylsulfonamido)-4-(2-methylsulfonyloxyethyl)-octanoate in 2 ml dimethylformamide is added 0.101 g imidazole and then the solution is heated at 100° for 8 h. The mixture is poured into water and extracted with ethyl acetate. The organic phase is washed with water (2×20 ml), dried, filtered and evaporated to give an amber oil which is purified by preparative thin layer chromatography using ethyl acetate as eluent to give methyl 8-(p-chlorophenylsulfonamido)-4-[2-(1-imidazolyl)ethyl]-octanoate as a yellow oil.

1. temperaturethe solution is heated at 100° for 8 h
2. extractionextracted with ethyl acetate
3. washThe organic phase is washed with water (2×20 ml)
4. customdried
5. filtrationfiltered
6. customevaporated
7. customto give an amber oil which
8. customis purified by preparative thin layer chromatography