反应详情

A solution of 2.9 g (5 mmol) of ethyl 8-[N-(p-chlorophenylsulfonyl)-N-(t-butoxycarbonyl)-amino]-4-[2-(3-pyridyloxy)ethyl]-octanoate in 30 ml trifluoroacetic acid is stirred at room temperature. After 18 h the reaction mixture is evaporated to dryness. The residue is dissolved in methylene chloride and the solution is washed with saturated NaHCO3 solution, dried and evaporated. The residue is chromatographed on silica gel using 1:1 ethyl acetate/methylene chloride as eluent to yield ethyl 8-(p-chlorophenylsulfonamido)-4-[2-(3-pyridyloxy)ethyl]-octanoate.

1. customAfter 18 h the reaction mixture is evaporated to dryness
2. dissolutionThe residue is dissolved in methylene chloride
3. washthe solution is washed with saturated NaHCO3 solution
4. customdried
5. customevaporated
6. customThe residue is chromatographed on silica gel using 1:1 ethyl acetate/methylene chloride as eluent