Butylamine → 2-(p-Fluorobenzoyl)-3-butylaminocrotononitrile

HRID 46564Notes

Reaction equation

HRID 46564 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6](/[C:8](=[C:11](/OC)\[CH3:12])/[C:9]#[N:10])=[O:7])=[CH:4][CH:3]=1.[CH2:17]([NH2:21])[CH2:18][CH2:19][CH3:20]>>[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6](/[C:8](=[C:11](/[NH:21][CH2:17][CH2:18][CH2:19][CH3:20])\[CH3:12])/[C:9]#[N:10])=[O:7])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8007ButylamineHCID 234685082-(p-Fluorobenzoyl)-3-methoxycrotononitrile

Product 1

HCID 705302592-(p-Fluorobenzoyl)-3-butylaminocrotononitrile

Procedure

A sample of 2.5 g. of 2-(p-fluorobenzoyl)-3-methoxycrotononitrile is dissolved in 10 ml. of n-butylamine. The solution is sealed in a stainless steel bomb and heated on a steam bath overnight. The bomb is then opened and the solvent evaporated under reduced pressure. A greenish oil is obtained which is distilled on a Kugelrohr apparatus at 200° C./0.1 mm. to obtain the yellow oily product.

Workup

  1. temperatureheated on a steam bath overnight
  2. customthe solvent evaporated under reduced pressure
  3. customA greenish oil is obtained which
  4. distillationis distilled on a Kugelrohr apparatus at 200° C./0.1 mm
  5. customto obtain the yellow oily product

Sources & evidence

ORD record
ord-b6cb3cc1b5644b3a951ee0f353086208
Source dataset
uspto-grants-1979_11
Patent number
US04173650

Reaction notes

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