Butylamine → 2-(p-Fluorobenzoyl)-3-butylaminocrotononitrile

Participants

Reaction Steps

A sample of 2.5 g. of 2-(p-fluorobenzoyl)-3-methoxycrotononitrile is dissolved in 10 ml. of n-butylamine. The solution is sealed in a stainless steel bomb and heated on a steam bath overnight. The bomb is then opened and the solvent evaporated under reduced pressure. A greenish oil is obtained which is distilled on a Kugelrohr apparatus at 200° C./0.1 mm. to obtain the yellow oily product.

Provenance & Evidence