Hydrochloric Acid → HCID 178467954, compound

HRID 46566Notes

Reaction equation

HRID 46566 reaction equation
[F:1][C:2]1[CH:17]=[CH:16][C:5]([C:6](/[C:8](=[C:11](/N(C)C)\[CH3:12])/[C:9]#[N:10])=[O:7])=[CH:4][CH:3]=1.Cl.C[OH:20]>>[F:1][C:2]1[CH:17]=[CH:16][C:5]([C:6](/[C:8](=[C:11](/[OH:20])\[CH3:12])/[C:9]#[N:10])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 234684972-(p-Fluorobenzoyl)-3-dimethylaminocrotononitrile

Product 1

HCID 178467954HCID 178467954, compound

Procedure

A solution of 1.35 g. (0.006 m) of 2-(p-fluorobenzoyl)-3-dimethylaminocrotononitrile in a mixture of 15 ml. methanol and 8 ml. of 1 N HCl was heated on the steam bath in an open beaker for 45 minutes. Upon cooling in an ice bath, a solid formed, was collected, and then recrystallized from cyclohexane-petroleum ether with charcoal treatment, giving 0.7 g. (64%) of light pinkish crystals, m.p. 65°-67° C.

Workup

  1. temperatureUpon cooling in an ice bath
  2. customa solid formed
  3. customwas collected
  4. customrecrystallized from cyclohexane-petroleum ether with charcoal treatment
  5. customgiving 0.7 g

Sources & evidence

ORD record
ord-b0ab40d4d4ac4b22833e7e55655796b5
Source dataset
uspto-grants-1979_11
Patent number
US04173650

Reaction notes

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