Benzoyl chloride → N-[2-[[2,6-bis(1-Methylethyl)phenyl]amino]-2-oxoethyl]-N-(9H-fluoren-9-yl)benzamide

HRID 465663Notes

Reaction equation

HRID 465663 reaction equation
[CH3:1][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:12])[CH3:11])[C:5]=1[NH:13][C:14](=[O:30])[CH2:15][NH:16][CH:17]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:3].[C:31](Cl)(=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.COC1C=CC=CC=1C(Cl)=O>>[CH3:3][CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:10]([CH3:11])[CH3:12])[C:5]=1[NH:13][C:14](=[O:30])[CH2:15][N:16]([CH:17]1[C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:29]=2[C:19]2[C:18]1=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:31](=[O:38])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH3:1]

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 889692-Methoxybenzoyl chlorideHCID 1645639N-[2,6-bis(1-Methylethyl)phenyl]-2-[(diphenylmethyl)amino]acetamide

Product 1

HCID 19874930N-[2-[[2,6-bis(1-Methylethyl)phenyl]amino]-2-oxoethyl]-N-(9H-fluoren-9-yl)benzamide

Procedure

When in the procedure of Example 94 an appropriate amount of product of Example 77 was substituted for the product of Example 4 and an appropriate amount of benzoyl chloride was substituted for 2-methoxybenzoyl chloride and the general procedure of Example 94 was followed the title compound was obtained. Total yield, 0.56 g (76%).

Sources & evidence

ORD record
ord-1a15f7ce90fc4a2eb881c5192b494086
Source dataset
uspto-grants-1992_10
Patent number
US05153226

Reaction notes

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