Triethylamine → HCID 178467956, compound

HRID 46569Notes

Reaction equation

HRID 46569 reaction equation
[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].[F:8][C:9]1[CH:22]=[CH:21][C:12]([C:13](/[C:15](=[C:18](/[OH:20])\[CH3:19])/[C:16]#[N:17])=[O:14])=[CH:11][CH:10]=1>C(OCC)C>[CH2:1]([NH+:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:13](/[C:15](=[C:18](/[OH:20])\[CH3:19])/[C:16]#[N:17])=[O:14])=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 178467954HCID 178467954, compound

Product 1

HCID 178467956HCID 178467956, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 1.3 ml. of triethyl amine in 10 ml. of diethyl ether is added dropwise to a solution of 1.5 g. of 2-(p-fluorobenzoyl)-3-hydroxycrotononitrile in 20 ml. of diethyl ether. After stirring for 1 hour, a yellow oil separated which crystallizes upon evaporation of the solvent. The product was filtered, washed with ether and dried, providing the title compound.

Workup

  1. customa yellow oil separated which
  2. customcrystallizes upon evaporation of the solvent
  3. filtrationThe product was filtered
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-ee0c6d3ae2294197b9917328490f80b1
Source dataset
uspto-grants-1979_11
Patent number
US04173650

Reaction notes

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