Aluminum(III) Chloride → HCID 19875211, compound

HRID 465694Notes

Reaction equation

HRID 465694 reaction equation
[Cl:1][C:2]1[C:7]([O:8]C)=[CH:6][C:5]([N:10]2[C:18]([C:19]#[N:20])=[C:13]3[CH2:14][CH2:15][CH2:16][CH2:17][N:12]3[C:11]2=[O:21])=[C:4]([F:22])[CH:3]=1.[Al+3].[Cl-].[Cl-].[Cl-]>C1C=CC=CC=1>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:10]2[C:18]([C:19]#[N:20])=[C:13]3[CH2:14][CH2:15][CH2:16][CH2:17][N:12]3[C:11]2=[O:21])=[C:4]([F:22])[CH:3]=1

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 53689025HCID 53689025, compound

Product 1

HCID 19875211HCID 19875211, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The product of Example 53, 2-(4-chloro-2-fluoro-5-methoxyphenyl)-2,3,5,6,7,8-hexahydro-3-oxoimidazo[1,5-a]pyridine-1-carbonitrile, (4 g, 0.012 mol) was dissolved in benzene and treated with 8.3 g (0.062 mol) of AlCl3 using conditions described in Example 32 to furnish 3.1 g of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,3,5,6,7,8-hexahydro-3-oxoimidazo[1,5-a]pyridine-1-carbonitrile (m.p. 204°-6° C.).

Sources & evidence

ORD record
ord-3b675cfac18d464b8e52cc827d4fef74
Source dataset
uspto-grants-1992_10
Patent number
US05153316

Reaction notes

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