Aluminum(III) Chloride → HCID 19875211, compound

Participants

Reaction Steps

The product of Example 53, 2-(4-chloro-2-fluoro-5-methoxyphenyl)-2,3,5,6,7,8-hexahydro-3-oxoimidazo[1,5-a]pyridine-1-carbonitrile, (4 g, 0.012 mol) was dissolved in benzene and treated with 8.3 g (0.062 mol) of AlCl3 using conditions described in Example 32 to furnish 3.1 g of 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-2,3,5,6,7,8-hexahydro-3-oxoimidazo[1,5-a]pyridine-1-carbonitrile (m.p. 204°-6° C.).

Provenance & Evidence