Water → HCID 67703958, compound

HRID 465722Notes

Reaction equation

HRID 465722 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.C[NH:13][CH2:14][CH2:15][CH3:16].O.[C:18](#N)C>>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[NH:13][CH2:14][CH2:15][CH3:16])=[C:4]([CH3:18])[N:3]=1

Participants

5

Reactant 4

HCID 962WaterHCID 6342AcetonitrileHCID 12315N-MethylpropylamineHCID 53603492-Amino-6-chloropurine

Product 1

HCID 67703958HCID 67703958, compound

Conditions

Temperature
75 °C

Procedure

2-Amino-6-chloropurine (Sigma, lot #69F4064, 6.0 g, 35.4 mmol) was suspended in 75mL acetonitrile. N-Methylpropylamine (Aldrich, lot #00923AW. 10.0 g, 136.7 mmol) was added and the reaction stirred at 75° C. for 24 hours. The solvents were evaporated to give an oil. Stirring the oil with water yielded a solid which was filtered and dried to give 5.9 g (28.6 mmol, 81%); mp=181°C.

Workup

  1. customThe solvents were evaporated
  2. customto give an oil
  3. customyielded a solid which
  4. filtrationwas filtered
  5. customdried
  6. customto give 5.9 g (28.6 mmol, 81%)

Sources & evidence

ORD record
ord-0b29bcb8ffc84e58a908163264c3237e
Source dataset
uspto-grants-1992_10
Patent number
US05153318

Reaction notes

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