Acetonitrile → HCID 67703971, compound

HRID 465725Notes

Reaction equation

HRID 465725 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4](Cl)[N:3]=1.C([NH:14][CH3:15])C.[C:16](#N)[CH3:17]>O>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[NH:14][CH3:15])=[C:4]([CH2:16][CH3:17])[N:3]=1

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 12219N-MethylethylamineHCID 53603492-Amino-6-chloropurine

Product 1

HCID 67703971HCID 67703971, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
75 °C

Procedure

2-Amino-6-chloropurine (Sigma, lot #69F4064, 6.5g, 38.3 mmol) was suspended in 75mL acetonitrile. N-Ethylmethylamine (6.8 g, 115.0 mmol) was added and the reaction stirred at 75° C. for 24 hours. The solvents were evaporated to give a solid which was slurried in H2O, filtered, and air dried to yield 4.86g (25.3 mmol, 66%); mp=206°C.

Workup

  1. customThe solvents were evaporated
  2. customto give a solid which
  3. filtrationfiltered
  4. customair dried
  5. customto yield 4.86g (25.3 mmol, 66%)

Sources & evidence

ORD record
ord-a1da1529b94c44ba9e03b622efd2bd0d
Source dataset
uspto-grants-1992_10
Patent number
US05153318

Reaction notes

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