Iodoethane → HCID 23345728, compound

HRID 46583Notes

Reaction equation

HRID 46583 reaction equation
[I-:1].Br[C:3]1[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)=[CH:7][N+:6]([CH3:19])=[CH:5][C:4]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH2:26]([I:28])C>>[I-:28].[CH2:19]([N+:6]1[CH:7]=[C:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[C:3]([I:1])=[C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:5]=1)[CH3:26]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 23345780HCID 23345780, compound

Product 1

HCID 23345728HCID 23345728, compound

Procedure

A 2 g. portion of the 4-bromopyridine intermediate of Example 9 was combined with 10 ml. of ethyl iodide and allowed to stand at room temperature for 3 days. Volatile materials were then evaporated under vacuum, and the solids were crystallized from chloroform-hexane, yield 0.25 g., m.p. 235°-238°. Analysis by nuclear magnetic resonance and mass spectrometry techniques identified the product as consisting of approximately 60 percent of the compound of Example 12, and approximately 40 percent of the compound of Example 13.

Workup

  1. customVolatile materials were then evaporated under vacuum
  2. customthe solids were crystallized from chloroform-hexane, yield 0.25 g

Sources & evidence

ORD record
ord-41046c819e2c455a88dc269d7d2474ec
Source dataset
uspto-grants-1979_11
Patent number
US04174209

Reaction notes

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