Cysteamine → HCID 17977486, compound

HRID 465897Notes

Reaction equation

HRID 465897 reaction equation
[NH2:1][CH2:2][CH2:3][SH:4].[C:5]1(=[O:15])[O:10][C:8](=[O:9])[CH:7]2[CH2:11][CH2:12][CH2:13][CH2:14][CH:6]12>CO>[SH:4][CH2:3][CH2:2][NH:1][C:5](=[O:15])[CH:6]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:7]1[C:8]([OH:10])=[O:9]

Participants

4

Reactant 2

HCID 6058Cysteamine2×HCID 85689Hexahydrophthalic anhydride

Product 1

HCID 17977486HCID 17977486, compoundYield 99.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 7.72 g (0.1 mole) of cysteamine in 40 cm3 of methanol, maintained under an inert atmosphere and cooled to a temperature between 0° and 5° C., there are added, by portions, 15.43 g (0.1 mole) of hexahydrophthalic anhydride. After 7 hours of stirring at this temperature, there remains only traces of the starting cysteamine. The solution is evaporated to dryness under reduced pressure at ambient temperature. 23 g of N-(2-mercapto ethyl) hexahydrophthalamic acid are obtained in the form of a colorless oil.

Workup

  1. temperaturecooled to a temperature between 0° and 5° C., there
  2. customThe solution is evaporated to dryness under reduced pressure at ambient temperature

Sources & evidence

ORD record
ord-2fe9dfaaee5c44a4a472a668b0547e7c
Source dataset
uspto-grants-1992_10
Patent number
US05154918

Reaction notes

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