反应详情

A solution of 52.8 g of methanesulphonyl chloride in 100 ml of toluene is added dropwise to a mixture of 52.6 g of 2,2-dimethylpiperazine, 69.9 g of potassium carbonate and 150 ml of toluene, the internal temperature rising to about 55° C. After a stirring time of 3 hours, the insoluble fraction is filtered off with suction and the toluene solution is evaporated in vacuo. The oil which remains gradually solidifies and is recrystallised from isopropanol for purification.

1. customrising to about 55° C
2. filtrationAfter a stirring time of 3 hours, the insoluble fraction is filtered off with suction
3. customthe toluene solution is evaporated in vacuo
4. customis recrystallised from isopropanol for purification