反应详情

1.24 g (10 mmol) of 2-amino-3-hydroxy-6-methylpyridine are introduced into a three-necked round-bottomed flask. The contents are placed under argon. 20 ml of anhydrous tetrahydrofuran and then 2.43 g (15 mmol) of 1,1-carbonyldiimidazole are added. The mixture is heated to reflux for 6 hours. The reaction medium is evaporated. The crystals obtained are washed with water, filtered off and redissolved in hot methanol. The solution is filtered and re-evaporated.

1. temperatureThe mixture is heated
2. temperatureto reflux for 6 hours
3. customThe reaction medium is evaporated
4. customThe crystals obtained
5. washare washed with water
6. filtrationfiltered off
7. dissolutionredissolved in hot methanol
8. filtrationThe solution is filtered
9. customre-evaporated