Methane → HCID 15745424, compound

HRID 465985Notes

Reaction equation

HRID 465985 reaction equation
[CH3:1][N:2]([CH2:10][CH2:11][N:12]1[C:16]2=[N:17][CH:18]=[CH:19][CH:20]=[C:15]2[O:14][C:13]1=[O:21])CC1C=CC=CC=1.C>CO>[CH3:1][NH:2][CH2:10][CH2:11][N:12]1[C:16]2=[N:17][CH:18]=[CH:19][CH:20]=[C:15]2[O:14][C:13]1=[O:21]

Participants

4

Reactant 2

HCID 297MethaneHCID 15745411HCID 15745411, compound

Product 1

HCID 15745424HCID 15745424, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a 1,000-cm3 ground-necked flask, 0.02 mol of 3-[2-(N-methyl-N-benzylamino)ethyl]-3H-oxazolo[4,5-b]pyridin-2-one is dissolved in 250 cm3 of methanol. 0.2 g of palladinized charcoal is introduced and the mixture is stirred under a hydrogen atmosphere at room temperature and atmospheric pressure. After absorption of the theoretical quantity of hydrogen, the reaction medium is filtered. The filtrate is concentrated on a water bath under vacuum and acidified with a stream of gaseous hydrochloric acid. The precipitate obtained is drained, dried and recrystallized.

Workup

  1. customAfter absorption of the theoretical quantity of hydrogen
  2. filtrationthe reaction medium is filtered
  3. concentrationThe filtrate is concentrated on a water bath under vacuum
  4. customThe precipitate obtained
  5. customdried
  6. customrecrystallized

Sources & evidence

ORD record
ord-ee9ae8bca53c420483e3697e04401380
Source dataset
uspto-grants-1992_10
Patent number
US05155116

Reaction notes

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