Isopropylamine → HCID 15745425, compound

HRID 465986Notes

Reaction equation

HRID 465986 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].Br[CH2:6][CH2:7][N:8]1[C:12]2=[N:13][CH:14]=[CH:15][CH:16]=[C:11]2[O:10][C:9]1=[O:17]>C(#N)C>[CH:1]([NH:4][CH2:6][CH2:7][N:8]1[C:12]2=[N:13][CH:14]=[CH:15][CH:16]=[C:11]2[O:10][C:9]1=[O:17])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 103771063-(2-Bromoethyl)oxazolo[4,5-b]pyridin-2(3H)-one

Product 1

HCID 15745425HCID 15745425, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.1 mol of isopropylamine and 0.01 mol of 3-(2-bromoethyl)-3H-oxazolo[4,5-b]pyridin-2-one, dissolved beforehand in 40 cm3 of acetonitrile, are introduced into a 100-cm3 ground-necked round-bottomed flask equipped with a reflux condenser. The mixture is heated to reflux for 15 hours. After cooling, the precipitate obtained is drained, dried and recrystallized.

Workup

  1. additionare introduced into a 100-cm3 ground-necked round-bottomed flask
  2. customequipped with a reflux condenser
  3. temperatureThe mixture is heated
  4. temperatureto reflux for 15 hours
  5. temperatureAfter cooling
  6. customthe precipitate obtained
  7. customdried
  8. customrecrystallized

Sources & evidence

ORD record
ord-7cfebfb08a1242a086cd6dc745ca372c
Source dataset
uspto-grants-1992_10
Patent number
US05155116

Reaction notes

Loading…