HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 465987Generated: October 30, 2026
Formaldehyde → 3-MORPHOLINOMETHYL-3H-OXAZOLO[4,5-b]PYRIDIN-2-ONE
https://huagongshe.com/reaction/465987
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Oxazolo(4,5-b)pyridin-2(3H)-one | HCID 2799900 | — |
| Product | 3-MORPHOLINOMETHYL-3H-OXAZOLO[4,5-b]PYRIDIN-2-ONE | HCID 15745427 | — |
Reaction Steps
4.1 g (0.03 mol) of 3H-oxazolo[4,5-b]pyridin-2-one are dissolved in 100 ml of alcohol at 95° C. 2.88 g (0.33 mol) of morpholine and then 3 ml of 30% aqueous formaldehyde solution are added. The mixture is stirred on a water bath at a temperature in the region of 50° C. for one hour 30 minutes, stirring being maintained. The mixture is left to stand for one hour at room temperature. The crystals are drained and recrystallized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05155116 |
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| Source dataset | uspto-grants-1992_10 |
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| ORD ID | ord-6cf0aa728b40496e8c2e5636e6579f0f |
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| Source note | uspto-grants-1992_10 |
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