Water → 2-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrile

HRID 466008Notes

Reaction equation

HRID 466008 reaction equation
[C:1]1([C:7]2[C:15]([CH2:16][C:17](=[N:21]O)C(O)=O)=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O>C(OC(=O)C)(=O)C>[C:1]1([C:7]2[C:15]([CH2:16][C:17]#[N:21])=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 962WaterHCID 536794283-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2-hydroxyiminopropionic acid

Product 1

HCID 151581752-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrileYield 63.3%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of 3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2-hydroxyiminopropionic acid (0.20 g) in acetic anhydride (1 ml) was stirred for an hour at 80° C. After cooling to the mixture was added water (10 ml). The resulting precipitates were collected by filtration to give 2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrile (0.10 g).

Workup

  1. temperatureAfter cooling to the mixture
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-b368828b07294ecd8abef5b55c62c453
Source dataset
uspto-grants-1992_10
Patent number
US05155114

Reaction notes

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