HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrile | HCID 15158175 | — |
| Product | 2-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid | HCID 15158170 | — |
Reaction Steps
A mixture of 2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrile (0.23 g), 85% sodium hydroxide (0.33 g) and 80% aqueous methanol was refluxed for 15 hours. The reaction mixture was acidified with 5% hydrochloric acid (pH≈1) and the precipitates were collected by filtration to give 2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid (0.23 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155114 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-e68fe73d1de940bda97a8dceb0ebd45e |
| Source note | uspto-grants-1992_10 |