Hydrochloric Acid → 2-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid

HRID 466009Notes

Reaction equation

HRID 466009 reaction equation
[C:1]1([C:7]2[C:15]([CH2:16][C:17]#N)=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:19].[Na+].Cl.C[OH:23]>>[C:1]1([C:7]2[C:15]([CH2:16][C:17]([OH:23])=[O:19])=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 151581752-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrile

Product 1

HCID 151581702-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid

Procedure

A mixture of 2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acetonitrile (0.23 g), 85% sodium hydroxide (0.33 g) and 80% aqueous methanol was refluxed for 15 hours. The reaction mixture was acidified with 5% hydrochloric acid (pH≈1) and the precipitates were collected by filtration to give 2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid (0.23 g).

Workup

  1. temperaturewas refluxed for 15 hours
  2. filtrationthe precipitates were collected by filtration

Sources & evidence

ORD record
ord-e68fe73d1de940bda97a8dceb0ebd45e
Source dataset
uspto-grants-1992_10
Patent number
US05155114

Reaction notes

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