HRID466091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10946

2-Chloroacetic anhydride

C4H4Cl2O3

结构：O=c1[nH]c(=O)n([C@H]2C[C@H](OCc3ccccc3)[C@@H](CO)O2)cc1F

HCID10664574

Uridine, 2'-deoxy-5-fluoro-3'-O-(phenylmethyl)-

C16H17FN2O5

PRODUCTS

生成物

结构：O=C(CCl)OC[C@H]1O[C@@H](n2cc(F)c(=O)[nH]c2=O)C[C@@H]1OCc1ccccc1

HCID13715089

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Chloroacetic anhydride was added to a solution of 0.20 g of 3'-O-benzyl-2'-deoxy-5-fluorouridine in 10 ml of pyridine, and the mixture was left to stand at room temperature overnight. Then the same subsequent procedures as in Reference Example 54 were conducted, giving 0.11 g of the title compound as an oil in a yield of 45%.

WORKUP

后处理

waitthe mixture was left