HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetic anhydride → 3'-O-benzyl-5'-O-chloroacetyl-2'-deoxy-5-fluorouridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetic anhydride | HCID 10946 | — |
| Reactant | Uridine, 2'-deoxy-5-fluoro-3'-O-(phenylmethyl)- | HCID 10664574 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3'-O-benzyl-5'-O-chloroacetyl-2'-deoxy-5-fluorouridine | HCID 13715089 | 45% |
Reaction Steps
Chloroacetic anhydride was added to a solution of 0.20 g of 3'-O-benzyl-2'-deoxy-5-fluorouridine in 10 ml of pyridine, and the mixture was left to stand at room temperature overnight. Then the same subsequent procedures as in Reference Example 54 were conducted, giving 0.11 g of the title compound as an oil in a yield of 45%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155113 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-57beb9c9f2e545fcbeda93ad0b45458f |
| Source note | uspto-grants-1992_10 |