反应详情

A 2.00 g quantity of 5-chloro-4-hydroxy-2-pyridone was refluxed in 150 ml of pyridine to obtain a uniform solution. To the solution was added 5.85 g of stearoyl chloride and the mixture was subjected to reaction at room temperature overnight. After completion of the reaction, the pyridine was concentrated and the concentrate was extracted with petroleum ether. The petroleum ether layer was concentrated and subjected to silica gel column chromatography using as an eluent petroleum ether-chloroform (1:9), giving 1.40 g of the title compound in a yield of 15%.

1. customto obtain a uniform solution
2. customthe mixture was subjected to reaction at room temperature overnight
3. customAfter completion of the reaction
4. concentrationthe pyridine was concentrated
5. extractionthe concentrate was extracted with petroleum ether
6. concentrationThe petroleum ether layer was concentrated