Acetyl chloride → 4-Acetoxy-2-pyridone
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.[C:9](Cl)(=[O:11])[CH3:10]>C(OCC)(=O)C>[C:9]([O:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1)(=[O:11])[CH3:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A 5.00 g quantity of 4-hydroxy-2-pyridone and 3.84 ml of acetyl chloride were reacted for 5 hours in the same manner as in Example 2. The title compound was isolated in an amount of 4.15 g from the reaction mixture in the same manner as in Example 2 except that ethyl acetate was used as extraction solvent. Yield was 60%.
Sources & evidence
- ORD record
- ord-c264df49bd2a4437b3ad8ab9d52c83da
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05155113
Reaction notes
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