Acetyl chloride → HCID 14049647, compound

HRID 466121Notes

Reaction equation

HRID 466121 reaction equation
[Cl:1][C:2]1[C:3]([OH:9])=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[C:10](Cl)(=[O:12])[CH3:11]>N1C=CC=CC=1>[C:10]([O:9][C:3]1[C:2]([Cl:1])=[CH:7][NH:6][C:5](=[O:8])[CH:4]=1)(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 54679224Gimeracil

Product 1

HCID 14049647HCID 14049647, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 5.00 g quantity of 5-chloro-4-hydroxy-2-pyridone and 3.66 ml of acetyl chloride were stirred in 250 ml of pyridine at room temperature for 3 hours. The reaction mixture was then concentrated and the concentrate was washed with ethyl acetate and water to produce 3.39 g of the title compound in a yield of 52%.

Workup

  1. concentrationThe reaction mixture was then concentrated
  2. washthe concentrate was washed with ethyl acetate and water

Sources & evidence

ORD record
ord-ac4372b4a3d243bcb68fec4e31af3e20
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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