反应详情

To a solution of 1.00 g of 4-hydroxy-2-pyridone and 2.00 g of 3-benzyloxycarbonylpropionic acid in 30 ml of dimethylformamide was added at room temperature 1.90 g of N,N'-dicyclohexylcarbodiimide with stirring and the mixture was stirred overnight. The crystals formed were filtered off and the filtrate was concentrated. The concentrate was dissolved in 50 ml of ethyl acetate and washed with 20 ml of water three times. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated. The concentrate was then subjected to silica gel column chromatography using as an eluent 2% methanol-chloroform, giving 0.62 g of the title compound in a yield of 23%.

1. stirringthe mixture was stirred overnight
2. customThe crystals formed
3. filtrationwere filtered off
4. concentrationthe filtrate was concentrated
5. dissolutionThe concentrate was dissolved in 50 ml of ethyl acetate
6. washwashed with 20 ml of water three times
7. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
8. concentrationconcentrated