Isobutyryl chloride → HCID 178454647, compound

HRID 466130Notes

Reaction equation

HRID 466130 reaction equation
C[Si](C)(C)[O:3][C:4]1[CH:9]=[C:8]([O:10][Si](C)(C)C)[CH:7]=[CH:6][N:5]=1.[CH3:17][CH:18]([CH3:22])[C:19](Cl)=[O:20]>C(Cl)Cl>[OH:10][C:8]1[CH:7]=[CH:6][N:5]=[C:4]([O:3][C:19](=[O:20])[CH:18]([CH3:22])[CH3:17])[CH:9]=1

Participants

4

Reactant 2

HCID 62325Isobutyryl chlorideHCID 21819823HCID 21819823, compound

Product 1

HCID 178454647HCID 178454647, compoundYield 16.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2.0 g of 2,4-bis(trimethylsilyloxy)-pyridine in 20 ml of methylene chloride was added 1.01 g of 2-methylpropionyl chloride and the mixture was stirred at room temperature for one hour. Following thereafter the general procedure of Example 27, 230 mg of the title compound was obtained in a yield of 16.1%.

Sources & evidence

ORD record
ord-59a61681b729497cabb68d737dd47b08
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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