4-Propoxybenzoyl chloride → HCID 14049672, compound

HRID 466139Notes

Reaction equation

HRID 466139 reaction equation
[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)[CH2:2][CH3:3].[OH:14][C:15]1[CH:20]=[CH:19][NH:18][C:17](=[O:21])[CH:16]=1>N1C=CC=CC=1>[CH2:1]([O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([O:14][C:15]2[CH:20]=[CH:19][NH:18][C:17](=[O:21])[CH:16]=2)=[O:10])=[CH:7][CH:6]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 124345744-Propoxybenzoyl chlorideHCID 546960044-Hydroxy-2(1H)-pyridinone

Product 1

HCID 14049672HCID 14049672, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A 2.14 g quantity of 4-n-propoxybenzoyl chloride was added to a suspension of 1.00 g of 4-hydroxy-2-pyridone in 30 ml of pyridine, and the mixture was stirred at room temperature for 4 hours. The reaction mixture was concentrated and the concentrate was washed with ethyl acetate and water, thereby producing 1.98 g of the title compound in a yield of 81%.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. washthe concentrate was washed with ethyl acetate and water

Sources & evidence

ORD record
ord-79dee03760b649ff9ad218c715f1372a
Source dataset
uspto-grants-1992_10
Patent number
US05155113

Reaction notes

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