4-Phenoxyphenyl propargyl ether → 6-phenoxy-2H-1-benzopyran

Participants

Reaction Conditions

Reaction Steps

4-Phenoxyphenyl propargyl ether (33.7 g, 150 mmol) in 50 mL of N,N-diethylaniline is added to refluxing (220° C.) N,N-diethylanile (300 ml) dropwise over a period of 10 minutes under nitrogen. The mixture is stirred at reflux for 8 hours, cooled and evaporated under high vacuum (bath temp. ~80° C.) to remove solvents. The residue is distilled to give 6-phenoxy-2H-1-benzopyran; b.p. 147°-150° C./0.5 mmHg.

Provenance & Evidence