Hydrazine hydrate (1:1) → HCID 10855987, compound

HRID 466246Notes

Reaction equation

HRID 466246 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7](SC)[C:6]([F:11])=[CH:5][N:4]=1.O.[NH2:13][NH2:14]>C(O)C>[CH3:1][S:2][C:3]1[N:8]=[C:7]([NH:13][NH2:14])[C:6]([F:11])=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 10921327HCID 10921327, compound

Product 1

HCID 10855987HCID 10855987, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1 liter (L) flask equipped with a condensor and thermometer was charged with 80g (0.42 moles) of 2,4-bis(methylthio)-5-fluoropyrimidine, 200 mL of ethanol and 105g (2.1 moles) of hydrazine hydrate. The reaction mixture was poured onto 350 mL of ice-water. The solid product was isolated by filtration. After washing with water, the product was dried under vacuum at 60° C. to give 62.8g (86 percent yield) of 2-methylthio-4-hydrazino-5-fluoropyrimidine having a melt point of 146°-147° C.

Workup

  1. customThe solid product was isolated by filtration
  2. washAfter washing with water
  3. customthe product was dried under vacuum at 60° C.

Sources & evidence

ORD record
ord-77729f719728431b91d461d74f36976e
Source dataset
uspto-grants-1992_10
Patent number
US05155221

Reaction notes

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