反应详情

A solution of 1.37 g (18 mmoles) of thioacetic acid in 30 ml of ethanol is neutralized exactly, in a nitrogen atmosphere, by the dropwise addition of a 40% strength aqueous KOH solution, and 3.7 g (15 mmoles) of 2-bromo-5-chloro-1-indanone (Example 1 (a)) are added. The reaction mixture is stirred for 1 hour at room temperature and poured into 200 ml of water. The product which crystallizes after some time is filtered off and introduced, under nitrogen, into 35 ml of a 5% strength aqueous NaOH solution. After stirring for 1 hour at room temperature, the pH is adjusted to 1 with 2 N hydrochloric acid and the crystalline precipitate is filtered off. The resulting 5-chloro-2-mercapto-1-indanone decomposes at 173°-175° C.

1. additionare added
2. customThe product which crystallizes after some time
3. filtrationis filtered off
4. additionintroduced, under nitrogen, into 35 ml of a 5% strength aqueous NaOH solution
5. stirringAfter stirring for 1 hour at room temperature
6. filtrationthe crystalline precipitate is filtered off
7. customdecomposes at 173°-175° C.