Ethanol → HCID 21734076, compound

Participants

Reaction Steps

To 3.6 ml of an ethanol solution containing 86.7 mg (0.1500 mmol) of 2,2'-dicyclohexylmethoxy-5,5'-bis(2-ethoxycarbonylethyl) biphenyl obtained in Reference Example 4, there was added 1.2 ml (1.2 mmol) of 1N sodium hydroxide solution and the mixture was agitated at room temperature. The solvent of the reaction mixture was evaporated off under reduced pressure and, to the resulting evaporated residue, water was added. The solution obtained was acidified adding IN hydrochloric acid to a pH of 1-2. The thus-formed precipitate was filtrated, washed with water and dried, whereby 75.9 mg (0.1454 mmol, 97%) of the title compound was obtained as a white solid.

Provenance & Evidence