Ethanol → HCID 21734076, compound

HRID 466314Notes

Reaction equation

HRID 466314 reaction equation
C(O)C.[CH:4]1([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20]([O:22]CC)=[O:21])=[CH:14][C:13]=2[C:25]2[CH:30]=[C:29]([CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])[CH:28]=[CH:27][C:26]=2[O:38][CH2:39][CH:40]2[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]2)[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.[OH-].[Na+]>Cl>[CH:40]1([CH2:39][O:38][C:26]2[CH:27]=[CH:28][C:29]([CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[CH:30][C:25]=2[C:13]2[CH:14]=[C:15]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])[CH:16]=[CH:17][C:12]=2[O:11][CH2:10][CH:4]2[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]2)[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 21734073HCID 21734073, compound

Product 1

HCID 21734076HCID 21734076, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To 3.6 ml of an ethanol solution containing 86.7 mg (0.1500 mmol) of 2,2'-dicyclohexylmethoxy-5,5'-bis(2-ethoxycarbonylethyl) biphenyl obtained in Reference Example 4, there was added 1.2 ml (1.2 mmol) of 1N sodium hydroxide solution and the mixture was agitated at room temperature. The solvent of the reaction mixture was evaporated off under reduced pressure and, to the resulting evaporated residue, water was added. The solution obtained was acidified adding IN hydrochloric acid to a pH of 1-2. The thus-formed precipitate was filtrated, washed with water and dried, whereby 75.9 mg (0.1454 mmol, 97%) of the title compound was obtained as a white solid.

Workup

  1. customobtained in Reference Example 4, there
  2. customThe solvent of the reaction mixture was evaporated off under reduced pressure and, to the resulting
  3. customevaporated residue, water
  4. additionwas added
  5. customThe solution obtained
  6. filtrationThe thus-formed precipitate was filtrated
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-f124ea1fef9e44d684d16e68748bf750
Source dataset
uspto-grants-1992_10
Patent number
US05155259

Reaction notes

Loading…