Hydrochloric Acid → HCID 21734075, compound

Participants

Reaction Steps

To 10 ml of an ethanol solution containing 183.3 mg (0.4147 mmol) of 2,2'-diethoxy-5,5'-bis(3-methoxycarbonylpropyl) biphenyl obtained in Reference Example 5, there was added 3.3 ml (3.3 mmol) of 1N sodium hydroxide solution and the mixture was agitated at room temperature for 24 hours. The solvent of the reaction mixture was evaporated off under reduced pressure and, to the resulting evaporated residue, water was added. The solution obtain was acidified by adding 1N hydrochloric acid to a pH of 1-2. The thus-formed precipitate was filtered, washed with water and dried, whereby 164 mg (0.3966 mmol, 96%) of the title compound was obtained as a white solid.

Provenance & Evidence