Hydrochloric Acid → HCID 21734075, compound

HRID 466316Notes

Reaction equation

HRID 466316 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][C:13]([O:15]C)=[O:14])=[CH:6][C:5]=1[C:17]1[CH:22]=[C:21]([CH2:23][CH2:24][CH2:25][C:26]([O:28]C)=[O:27])[CH:20]=[CH:19][C:18]=1[O:30][CH2:31][CH3:32])[CH3:2].[OH-].[Na+].Cl>C(O)C>[CH2:31]([O:30][C:18]1[CH:19]=[CH:20][C:21]([CH2:23][CH2:24][CH2:25][C:26]([OH:28])=[O:27])=[CH:22][C:17]=1[C:5]1[CH:6]=[C:7]([CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:8]=[CH:9][C:4]=1[O:3][CH2:1][CH3:2])[CH3:32]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21734072HCID 21734072, compound

Product 1

HCID 21734075HCID 21734075, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 10 ml of an ethanol solution containing 183.3 mg (0.4147 mmol) of 2,2'-diethoxy-5,5'-bis(3-methoxycarbonylpropyl) biphenyl obtained in Reference Example 5, there was added 3.3 ml (3.3 mmol) of 1N sodium hydroxide solution and the mixture was agitated at room temperature for 24 hours. The solvent of the reaction mixture was evaporated off under reduced pressure and, to the resulting evaporated residue, water was added. The solution obtain was acidified by adding 1N hydrochloric acid to a pH of 1-2. The thus-formed precipitate was filtered, washed with water and dried, whereby 164 mg (0.3966 mmol, 96%) of the title compound was obtained as a white solid.

Workup

  1. customobtained in Reference Example 5, there
  2. customThe solvent of the reaction mixture was evaporated off under reduced pressure and, to the resulting
  3. customevaporated residue, water
  4. additionwas added
  5. customThe solution obtain
  6. filtrationThe thus-formed precipitate was filtered
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-26dfc0ac20504382b9e99c53613e1681
Source dataset
uspto-grants-1992_10
Patent number
US05155259

Reaction notes

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