反应详情

To a solution of 148 mg (0.4 mmol) of methyl 4-[1-hydroxy-3(2-hydroxy-5-trimethylsilylphenyl)-3-oxo-1-propenyl]benzoate in 20 ml of ethanol was added 2 ml of 2N-sodium hydroxide solution at room temperature with stirring. The mixture was stirred at room temperature for 1 day and acidified with 10%-hydrochloric acid to pH 4. A deposited precipitation was extracted with AcOEt. The extract was washed with H2O and saturated aq.NaCl, dried over MgSO4, and evaporated. The residue was recrystallized from methanol to give 72 mg of yellow needles (yield 51%), m.p. 207°-209° C.

1. stirringThe mixture was stirred at room temperature for 1 day
2. customA deposited precipitation
3. extractionwas extracted with AcOEt
4. washThe extract was washed with H2O
5. dry with materialNaCl, dried over MgSO4
6. customevaporated
7. customThe residue was recrystallized from methanol