HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → N-[2-(bromoacetyl)phenyl]methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-(4-acetylphenyl)-4-methylbenzene-1-sulfonamide | HCID 563797 | — |
| Reactant | N-[4-(2-Bromoacetyl)phenyl]-4-methylbenzenesulfonamide | HCID 16637184 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-[2-(bromoacetyl)phenyl]methanesulfonamide | HCID 18380501 | — |
Reaction Steps
In a similar manner 4'-(2-bromoacetyl)-p-toluenesulfonanilide, (m.p. 174°-1765° with decomposition,) can be prepared by bromination of 4'-acetyl-p-toluenesulfonanilide (Preparation 1) [See R. H. Vloth, et al., J. Med. Chem. 9, 88 (1966)]. For this preparation anhydrous ether can also be used as solvent; benzoyl peroxide can be used as a catalyst. The product is crystallized from acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155268 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-ff169a4c8b5940bf8693f970e8c7b5ac |
| Source note | uspto-grants-1992_10 |