HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2,6-Difluoro-4-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2,6-Difluoro-4-methoxybenzoic acid | HCID 2778228 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2,6-Difluoro-4-methoxybenzoyl chloride | HCID 2778768 | — |
Reaction Steps
A solution of oxalyl chloride (36.5 g, 0.29 mol) in dry benzene (50 ml) was added dropwise to a stirred solution of compound 24 (25.5 g, 0.14 mol) and dry DMF (40 drops) in dry benzene (500 ml) at room temperature. The mixture was stirred at room temperature overnight and the excess of oxalyl chloride and benzene were removed in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05156763 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-4accdac8a97c4df19fd1dc2bd631cea3 |
| Source note | uspto-grants-1992_10 |